The Ophthalmology Reimbursement Landscape
A big top line built on a thin, contested drug margin.
In ophthalmology, gross revenue and real margin are two different stories — the anti-VEGF book inflates the top line while the true economics sit in surgical mix, site of service, and cash-pay upgrades.
Retina practices acquire aflibercept, ranibizumab, and bevacizumab — and now their biosimilars — and bill them buy-and-bill under Part B at ASP plus a statutory add-on that sequestration has quietly compressed. A single injection can carry thousands of dollars of drug cost passing straight through the P&L, so headline revenue balloons while the retained spread stays narrow and exposed to ASP resets, biosimilar substitution, step therapy, and white-bagging mandates that move the drug to the pharmacy benefit entirely.
Meanwhile the durable economics live elsewhere: cataract volume and its migration to the ASC site of service, premium-IOL and refractive cash upgrades that sit outside the fee schedule, MIGS glaucoma procedures, and diagnostics such as OCT and optometric co-management. The same practice can be worth dramatically different amounts depending on how the drug book is contracted, how surgical cases are sited, and how cash-pay is priced — and that is precisely where Fulcrum works.
Illustrative composition. Replace with your confirmed figures before launch; reflects current CMS/Medicare Part B ASP methodology and public payer data, 2024–2026.